![(1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl- 2- [(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide CAS: 2628280-40-8 Whakaahua Whakaatu](http://cdn.globalso.com/xdbiochems/白色粉末2127.jpg)
![(1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl- 2- [(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide CAS: 2628280-40-8](http://cdn.globalso.com/xdbiochems/粉末238.jpg)
(1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl- 2- [(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide CAS: 2628280-40-8
| Nama Putumōhio | XD93399 |
| Ingoa Hua | (1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl- 2-[(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide |
| CAS | 2628280-40-8 |
| Papanga Molecularla | C23H32F3N5O4 |
| Taumaha rāpoi | 499.53 |
| Nga Taipitopito Rokiroki | Ambient |
Whakatakotoranga Hua
| Te ahua | Te paura ma |
| Ahahay | 99% min |
Ko te pūhui (1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3- dimethyl-2- [(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide he pūhui matatini me te tino motuhake me nga momo tono pea i roto rangahau rongoa me te whanaketanga tarukino.No te karaehe e kiia nei ko te azabicyclohexane carboxamides tenei puhui, e mohiotia ana he nui nga mahi koiora.He pūhui kirikiri, kei roto i nga pokapū stereo rereke, e tohuhia ana e te tohu (1R,2S,5S).He mea nui te noho o te hauhautanga na te mea ka pa ki nga ahuatanga koiora o te puhui me te taunekeneke ki nga taumata koiora.Ko tana hanganga ahurei me te stereochemistry e whakarato ana i nga whai waahi mo nga rangahau hononga hanganga-mahi (SAR) me te arotautanga arahi.Ka taea e nga kairangahau rongoa te whakarereke i nga rohe rereke o te ngota ngota ki te tirotiro ka pehea te paanga o enei huringa ki ana taunekeneke ki nga whaainga koiora, penei i nga enzymes, nga kaiwhakawhiwhi, me nga kaikawe.Ka taea te whakamahi i tenei matauranga ki te whakawhanake i nga raau taero kaha ake me te whiriwhiri mo nga momo mate.He whākōkī e whai wāhi nui ana i roto i ngā momo hātepe koiora me te whai wāhi ki ngā mate pēnei i te mate pukupuku, te HIV, me te mate mumura.Ko te whirihoranga motuhake me nga roopu mahi o tenei puhui ka waiho hei kaitono pai mo te whakawhanake i nga aukati protease me te pai ake o te kaha me te whiriwhiringa. I tua atu, ko te noho o te roopu o te roopu cyano me te mowhiti pyrrolidine e tohu ana tera pea he mahi ki nga mate huakita me nga mate harore.Ka taea te whakarereke i nga hanganga ki te whakarei ake i ona taonga antibacterial, antifungal ranei, me te arahi ki te whakawhanaketanga o nga matū antimicrobial hou. I tua atu, ko te noho o te roopu trifluoroacetyl e tohu ana ka whai waahi pea te pūhui hei prodrug.Ko nga Prodrugs he puhui hohekore, he iti ake ranei te kaha ka taea te huri ki roto i te tinana.Ka taea e te roopu trifluoroacetyl te mahi hei roopu whakamarumaru huna ka taea te wehe ki te tuku i te ngota ngota tarukino kaha ki te waahi mahi e hiahiatia ana.Ka taea e tenei rautaki te whakapai ake i te koiora o te tarukino, te whakarewatanga, te tuku ranei ki nga kopa motuhake.I te mutunga, ko te pūhui (1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin -3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1. 0]hexane-2-carboxamide e mau ana i te oati hei puhui utu nui mo te rangahau rongoa me te whanaketanga tarukino.Ko tana hanganga matatini, stereochemistry, me nga roopu mahi he maha nga whai waahi ki te hoahoa me te whakahiato i nga raau taero hou, te torotoro i te aukati protease, te whakawhanake i nga maatete antimicrobial, me te whakamahi rautaki prodrug.Ko te rangahau me te torotoro haere i ana mahi koiora me te kaha o te rongoa ka arai pea ki nga waahi rongoa rereke.
