4-Aminophthalhydrazide AMPPD Cas:3682-14-2 Kowhai marama ki te amipere ki te paura matomato pouri ki te putunga
| Nama Putumōhio | XD90156 |
| Ingoa Hua | 4-Aminophthalhydrazide |
| CAS | 3682-14-2 |
| Tātai rāpoi | C8H7N3O2 |
| Taumaha rāpoi | 177.16 |
| Nga Taipitopito Rokiroki | Toa i RT |
Whakatakotoranga Hua
| Te ahua | Kowhai marama ki te amipere ki te paura matomato pouri ki te puranga |
| Ahahay | ≥98.0% |
| Kiato | 1.433 |
| Te rewa | 300ºC |
| Kohuatanga | 633°C i te 760 mmHg |
| Ira hiko | 336.7°C |
| Wairewa | Wairewa i roto i te haukinia waikawa, te konutai warowaiha, tetahi atu turanga ranei. |
1.I tātarihia, ka whakatauritehia te paanga o nga H1-antihistamines e rima ki runga i te pupuhi oxidative i whakaihiihihia i te taumata taapiri me te taumata intracellular o te polymorphonuclear leukocytes motuhake me te whakaihiihi i te tangata.Ko te pakaru o nga neutrophils tangata motuhake i akohia e te luminol me te isoluminol whakarei chemiluminescence.Ko enei e whai ake nei Ko te raupapa o te kaha mo te H1-antihistamines ki te whakaheke i te chemiluminescence i arotakea extracellularly: dithiaden> loratadine> chlorpheniramine> brompheniramine> pheniramine me te waahi intracellular: loratadine> dithiaden.H1-antihistamines he rereke te rereke i runga i o raatau hanganga matū hei whakakore i te pupuhi o te oxidative e rua. - me te waahi intracellular o nga neutrophils tangata whakahihiri taratahi.
Ko nga punaha 2.Chemiluminescence e whakareihia ana e te isoluminol, te luminol ranei me te peroxidase he tikanga tairongo mo te kite i nga momo hāora urupare (ROS) i hangaia e te phagocyte NADPH oxidase.He rite tonu te hanganga o nga taputapu whakakaha e rua, he rereke noa iho i te tuunga o te roopu amino i roto i te whakakai kakara o nga ngota ngota.Ko tenei rereketanga ka huri te isoluminol he ngota ngota lipophilic iti ake te uru ki nga kiriuhi koiora.Ko te whakamahinga o te isoluminol ka herea ki nga rangahau e pa ana ki te hunanga o nga metabolites hāora.I roto i tenei rangahau ka whakaatuhia e matou ko nga peptides synthetic i puta mai i te rohe N-terminal o te konupūmā-regulated protein annexin AI ka pokanoa ki te kitea o nga rauropi i roto i te isoluminol-whakakaha, engari kaore i roto i te punaha-whakanui-a-luminol.Ko nga peptides i ahu mai i te annexin AI ka whakaiti i te putanga marama me te isoluminol e hikaka ana e te superoxide me te horseradish peroxidase (HRP) i roto i te formyl-methionyl-leucyl-phenylalanine- me te phorbol i aku ristate acetate-stimulated pūtau, me te hydrogen peroxide me te HRP.Kaore i te mohiotia te tikanga tika mo te aukati.Ko nga hua e whakaatuhia ana e tino kii ana me whakapumau te whakahokinga waea whakaheke i kitea me te chemiluminescence kua whakakaha-isoluminol me tetahi tikanga rereke hei whakatau i te tukunga o nga anion superoxide me te hydrogen peroxide.
