Hua

Tekau ma rima nga konukawata (II) -i hangaia nga metallointercalators kua whakahiatohia e whakamahi ana i nga hononga 1,10-phenanthroline (phen) kua whakakapihia, tae atu ki te 5-chloro-1,10-phenanthroline (5-Cl-phen), 5-methyl-1,10- phenanthroline (5-CH3-phen), 5-amino-1,10-phenanthroline (5-NH2-phen), 5-nitro-1,10-phenanthroline (5-NO2-phen) me te dipyrido[3,2-d :2',3'-f]quinoxaline (dpq), me te achiral ethylenediamine (en) me nga herenga ancillary chiral 1S,2S-diaminocyclohexane (S,S-dach) me 1R,2R-diaminocyclohexane (R,R-dach) .I whakatauhia to ratau cytotoxicity i roto i te L1210 murine leukemia cell line ma te whakamahi i nga whakamatautau aukati tipu.Ko nga huinga konganuku cytotoxic tino pai ko era kei roto nga herenga taapiri S,S-dach me nga hononga honohono 5-CH3-phen.Kotahi te metallointercalator [Pt(5-CH3-phen)(S,S-dach)]Cl2 (5MESS), e whakaatu ana i te pikinga o te cytotoxicity e 5-10-whakaritea ki te cisplatin kaihoko haumanu.Mai i nga whakamatautau mo te herenga DNA karekau he rereketanga nui i waenga i tetahi o nga matatini whakarewa, e tohu ana ko te hononga herenga DNA me te ahua o te herea/te taapiri DNA i hanga ko te mea anake te whakatau i te cytotoxicity o tenei whanau o te konukawata(II) -based. metallointercalators.