5-Sulfosalicylic acid dihydrate Cas: 5965-83-3 Ma ki te karaihe ma-kore
| Nama Putumōhio | XD90230 |
| Ingoa Hua | 5-Sulfosalicylic acid dihydrate |
| CAS | 5965-83-3 |
| Tātai rāpoi | C7H10O8S |
| Taumaha rāpoi | 254.215 |
| Nga Taipitopito Rokiroki | Ambient |
| Waehere Rere Whakariterite | 29182900 |
Whakatakotoranga Hua
| pūkawa | 5.5% mōrahi |
| makuku | 22% te teitei |
| Te ahua | Maama ki te karaihe ma-kore |
| Te waikawa katoa | 99 - 104% |
| Te whakamatautau | 99% |
Ka tirotirohia nga polycations hei kaikawe ki te tuku waikawa nucleic rongoa.Ko nga polycations he koretake te rongoa me te mahi anake ki te kawe utanga rongoa.Ko tenei rangahau e whakaatu ana i te whakahiatotanga o te polycation self-immolative (DSS-BEN) i runga i te rongoa polyamine analog N(1),N(11)-bisethylnorspermine (BENSpm).I hoahoatia te polycation ki te mahi takirua hei kawe kawe ira me te prodrug e aro ana ki te mate polyamine dysregulated i roto i te mate pukupuku.Ma te whakamahi i te whakakotahitanga o te NMR me te HPLC, ka whakapumautia e matou ko te polycation whaiaro-immolative ka paheketanga intracellular ki te tarukino matua BENSpm.Ko te BENSpm kua tukuna he whakaheke i nga taumata pūtau o te spermidine me te spermine me te whakahou i te polyamine catabolic enzymes spermine/spermidine N(1)-acetyltransferase (SSAT) me te spermine oxidase (SMO).Ko nga polycations kua whakahiatohia he polyplexes me te DNA me te whakahaere i te whakawhitinga pai.Ma te whakamahi i te kaha o te BENSpm ki te whakakorikori i nga pūtau mate pukupuku ki te apoptos-a-TNFα, ka whakaatuhia e te DSS-BEN te whakarei ake i te mahi patu pūtau o te maimoatanga ira TNFα.Ko nga kitenga kua whakaatuhia e whakamana ana i te DSS-BEN hei punaha tuku mahi-rua ka taea te tuku i te ira rongoa me te whakapai ake i te putanga o te rongoa ira hei hua o te whakahekenga intracellular o DSS-BEN ki te BENSpm me te painga o muri mai o BENSpm i runga i te polyamine dysregulated. pākia i roto i te mate pukupuku.
