D-Mannitol Cas: 69-65-8 96-101.5% Te paura tioata ma
| Nama Putumōhio | XD90226 |
| Ingoa Hua | D-Manitol |
| CAS | 69-65-8 |
| Tātai rāpoi | C6H14O6 |
| Taumaha rāpoi | 182.1718 |
| Nga Taipitopito Rokiroki | Ambient |
| Waehere Rere Whakariterite | 29054300 |
Whakatakotoranga Hua
| Te Whakarewa | 164 - 169 Deg C |
| Kōeke | BP |
| Te hurihanga motuhake | +23 - +25 |
| AS | <1ppm |
| Ngaronga i te whakamaroke | <0.3% |
| pūkawa | <0.01% |
| Te whakamatautau | 96 - 101.5% |
| Nickel | ≤ 1ppm |
| Waikawa | <0.2ml |
| Te Whakaheke Huka | ≤ 0.1% |
| Te kawe | ⩽ 20us/cm |
| Cl | <0.007% |
| Te ahua | Te paura tioata ma |
Hei tirotiro i te mahi o te ahotea oxidative me/ranei te mate mitochondrial i te puta mai o te whara o te whatukuhu (AKI) i te wa o te sepsis, i whakawhanakehia e matou he tauira i roto i te in vitro i hangaia e te sepsis ma te whakamahi i nga pūtau epithelial tubular proximal e kitea ana ki te endotoxin kitakita (lipopolysaccharide, LPS).Kua whakaratohia e tenei rangahau nga ahuatanga matua mo te hononga i waenga i te ahotea oxidative me nga koha mahi mekameka rewharewha mitochondrial.Ko te maimoatanga LPS i piki ake te whakahuatanga o te inducible nitric oxide synthase (iNOS) me te NADPH oxidase 4 (NOX-4), e whakaatu ana i te kaha o te cytosolic o te waikura nitric me te anion superoxide, nga momo hauota tauhohenga tuatahi (RNS) me nga momo hāora urupare. (ROS).Ko te ahua o tenei ahua hāora ki te haukoti i te mitochondrial oxidative phosphorylation ma te whakaiti i te mahi cytochrome c oxidase.Ko te mutunga mai, ka raru te kawe irahiko me te kumara iraoho puta noa i te membrane o roto mitochondrial, ka heke iho te kaha o te membrane mitochond rial, te tukunga o nga mea whakapouri apoptotic me te paheketanga o te adenosine triphosphate.Ko te mea whakamiharo, i muri i te whaainga o te RNS me te ROS, ka huri te mitochondria hei kaihanga o te ROS, na reira ka whai waahi ki te whakanui ake i te koretake o te mitochondrial.Ko te mahi a te hunga oxidants i roto i te mate o te mitochondrial i whakapumauhia ake e te whakamahi i nga aukati iNOS, i nga antioxidants ranei e pupuri ana i te mahi cytochrome c oxidase me te aukati i te pakaru o te membrane mitochondrial.Ko enei hua e kii ana ko te AKI i uru ki te sepsis ehara i te mea ko te kore o te mana o te kaha engari ano he urupare whakauru, tae atu ki nga kaupapa whakawhiti, tohu tohu ROS, mahi mitochondrial me te tuunga metabolic penei i te apoptosis.
