Doxorubicin hydrochloride CAS:25316-40-9 99% Karaka-whero paura Tioata
| Nama Putumōhio | XD90367 |
| Ingoa Hua | Doxorubicin hydrochloride |
| CAS | 25316-40-9 |
| Tātai rāpoi | C27H29NO11·HCl |
| Taumaha rāpoi | 579.98 |
| Nga Taipitopito Rokiroki | 2 ki te 8 °C |
| Waehere Rere Whakariterite | 29419000 |
Whakatakotoranga Hua
| WaiIhirangi | ≤ 4.0% |
| pH | 4.0-5.5 |
| Wairewa | Wairewa ki: wai, mewaro me te NaCl(aq) isotonic.He ngoikore te wairewa i roto i te chloroform me etahi atu whakarewa pararopi. |
| Nga Taonga Paanga | Doxorubicinone: ≤0.5% / Danunorubicin: ≤0.5% |
| Te whakamatautau | 99% |
| Wairewa toenga | Acetone me te waipiro: ≤2.5% / Acetone: ≤0.5% / Methanol: ≤500ppm |
| Tetahi atu poke | ≤ 0.5% |
| Nga poke katoa | ≤ 2.0% |
| Te kirikiriata | Ka tutuki ki te USP |
| Te ahua | Karaka-whero Te paura tioata |
| Tautuhinga | HPLC |
Ko nga turoro me te P-glycoprotein me te HER2/neu (HER2) te kaikawe-nui te whakaputa i te mate pukupuku uma he kino nga putanga haumanu.Heoi ano, karekau he rarangi waea mate pukupuku uma e waatea ana mo te hokohoko he HER2/P-glycoprotein he pai-rua, e whakawhäiti ana i nga rangahau mo tenei mara. Ka ripoatahia e matou te whanaketanga me te tohu o te raina iti-atete ki te tarukino mai i te uma HER2 pai. raina pūtau mate pukupuku ma te whakawhiti pūmau o te ATP-binding cassette (ABC) subfamily B mema 1 (ABCB1) ira e whakawaehere ana i te P-glycoprotein.I teitei ake nga taumata whakaaturanga ira ira ABCB1 i muri i te whakawhitinga, i hua ai te pikinga o te P-glycoprotein e 40 nga wa. whakapuakitanga.Ko te mea whakamiharo, ko te whakawhitinga o te ABCB1 i arai ano ki te piki iti o te ira HER2 me nga taumata whakapuaki pūmua.Ko te whakawhitinga o te ABCB1 i tino piki ake nga taumata whakaputanga P-glycoprotein. Ko te tikanga e whakamahia ana i konei mo te whakawhanake i tenei raina pūtau e tika ana mo te whakauru tere, pumau o te aukati tarukino P-glycoprotein-mediated ki nga tikanga taapiri.Ko te whakamatautau cytotoxicity in vitro e kii ana ko tenei raina pūtau he aukati-whakawhiti ki te whānuitanga o nga momo rongoa chemotherapeutic.
