Hua

Kua kitea te pūmua o te cerebral dopamine neurotrophic factor (CDNF) ki te tiaki i te ara dopaminergic nigrostriatal ina hoatu hei whaowhia i roto i nga tauira kiore me nga kiore o te mate Parkinson (PD).I roto i tenei rangahau, i aromatawaihia e matou te paanga neuroprotective o te CDNF i tukuna me te recombinant adeno-associated viral (AAV) serotype 2 vector i roto i te kiore 6-hydroxydopamine (6-OHDA) tauira o PD.AAV2 vectors whakawaehere CDNF, glial cell line-derived neurotrophic factor (GDNF), or green fluorescent pūmua i werohia ki roto ki te striatum kiore.I whakaatu mai te tātari korero pūmua ko ta maatau AAV2 vector i kawe pai nga ira tauwehe neurotrophic ki roto i te roro, ka puta he whakaaturanga roa o nga pūmua.E rua wiki i muri mai i te werohanga vector AAV2, ka werohia te 6-OHDA ki roto i te striatum kiore, ka puta te heke haere o te punaha dopaminergic nigrostriatal.Ko te maimoatanga me te AAV2-CDNF i tino heke iho nga hurihanga ipsilateral na te amphetamine-induced i te wa e whakarato ana i te whakamarumaru waahanga noa o nga pūtau tyrosine hydroxylase (TH) -immunoreactive i roto i te kiore substantia nigra pars compacta me nga muka TH-reactive i roto i te striatum.Ko nga hua mai i tenei rangahau he taunakitanga taapiri ka kiia ko te CDNF he rongoa pea mo te mate a Parkinson.