Hua

Ko te Islet amyloid polypeptide (IAPP; e mohiotia ana ko amylin) te kawenga mo te hanganga o te islet amyloid i roto i te momo mate huka momo 2, a ko te paitini a IAPP e whakaponohia ana ka whai waahi ki te ngaro o te papatipu β-cell e pa ana ki nga waahanga mutunga o te mate huka momo 2.Ka whai waahi ano te hanga o te motu amyloid ki te korenga o te whakato i muri i te whakawhitinga.Ka hangaia te IAPP hei prohormone, pro-islet amyloid polypeptide (proIAPP), ka tukatukahia i roto i nga kirikiri huna o nga β-cell pancreatic.Ka kitea etahi momo proIAPP kua tukatukahia i roto i nga putunga amyloid;Ko te mea tino rongonui ko te 48-toenga takawaenga, proIAPP(1-48), kei roto ko te N-terminal pro-extension, engari kua tika te tukatuka i te C-terminus.Ka whai waahi pea te tukatuka kaore i oti i roto i te hanganga o te motu amyloid ma te whakatairanga i nga taunekeneke me nga proteoglycans sulfated o te matrix extracellular, e whakatairanga ana i te hanganga amyloid.Ka whakaatuhia e matou ko te waikawa fuchsin (3-(1-(4-amino-3-methyl-5-sulphonatophenyl)-1-(4-amino-3-sulphonatophenyl)methylene)cyclohexa-1,4-dienesulphonic acid), he ngawari ko te sulfonated triphenyl methyl derivative, he aukati kaha o te hanga amyloid e te proIAPP(1-48) takawaenga.Ko te pärönaki mewaro triphenyl uaua ake te FCF tere matomato {ethyl-[4-[[4-[ethyl-[(3-sulfophenyl)methyl]amino]phenyl]-(4-hydroxy-2-sulfophenyl)methylidene]-1-cyclohexa -2,5-dienylidene]-[(3-sulfophenyl)methyl]azanium} ka aukati hoki i te hanganga amyloid na IAPP me te takawaenga tukatuka proIAPP.Ko nga puhui e rua ka aukati i te hanga amyloid ma nga ranunga o te takawaenga proIAPP me te tauira glycosaminoglycan heparan sulfate.Ko te waikawa fuchsin hoki ka aukati i te hanga amyloid-whakawaenga-a- glycosaminoglycan e te IAPP pakeke.Ko te kaha ki te aukati i te hanga o te amyloid ehara i te mea noa na te whakangao o nga pūhui, na te mea ko te aukati sulfonated o te amyloid-β, te tramiprosate, ehara i te aukati o te hanga amyloid na proIAPP(1-48).