L-Glutamine Cas: 56-85-9 99% White paura
| Nama Putumōhio | XD90309 |
| Ingoa Hua | L-Glutamine |
| CAS | 56-85-9 |
| Tātai rāpoi | C5H10N2O3 |
| Taumaha rāpoi | 146.1445 |
| Nga Taipitopito Rokiroki | Ambient |
| Waehere Rere Whakariterite | 29241900 |
Whakatakotoranga Hua
| Paemahana Rokiroki | +20 Deg C |
| Taumaha rāpoi | 146.14 |
| Te whakamatautau | 99.0% min |
| Te ahua | Te paura ma |
1.Ko te kano kano kano kawa o mua o te pūtau-T (ETP-ALL) he momo iti morearea o te kano kano tangata e kore e tino marama ki te taumata ngota.I konei ka ripoatahia e matou nga whakawhitinga e aro ana ki te maihao konutea E-pouaka-whakapiri i te tauwehe whakawhiti ZEB2 hei reanga ira e mau tonu ana i roto i te pakeketanga/ETP-KATOA.Ma te whakamahi i te tauira kiore hua-a-mahi, e whakaatu ana ko te whakapuaki Zeb2 mau tonu ka timata te reukemia T-cell.I tua atu, ka whakaatuhia e te Zeb2-driven kiore leukemia etahi ahuatanga o te hainatanga ira tangata kore pakeke/ETP-ALL, tae atu ki te kaha o te rewharewha-whakakotahitanga me te whakahohe i a Janus kinase (JAK)/whakawhiti tohu tohu me nga kaiwhakahoaho o te tuhi (STAT) e tohu ana ma te Whakahohenga whakawhiti o IL7R.Ko tenei rangahau e whakaatu ana i te ZEB2 he oncogene i roto i te koiora o te kore pakeke / ETP-ALL me te para i te huarahi ki te rangahau i mua i te haumanu o nga pūhui hou mo te maimoatanga o tenei momo iti kaha o te tangata T-KATOA ma te whakamahi i ta maatau tauira kiore a Zeb2.
2.Pluripotency, self-renewal, and differentiation are special features of embryonic stem (ES) cells, there provide values perspectives in regenerative medicine.Ko nga tukanga whakawhanaketanga e hiahia ana ki te whakahaere pai, ko te nuinga o nga mea e whakahaerehia ana e nga huarahi rongonui JAK/STAT, PI3K/AKT, me ERK/MAPK.Ko nga SPREDs (Sprouty related proteins with EVH1 domain) i kitea hei aukati i te huarahi tohu ERK/MAPK, i te mea kaore he mea i mohiotia mo o raatau mahi i roto i nga ruma ES me te wa o te rereketanga o mua, i tenei wa. ngā pūtau hei tātari i ngā mahi o ngā pūmua SPRED i roto i ngā pūtau ES me te wā rerekētanga moata.Ko te korero nui o nga SPRED ka tino whakanui ake i te whakahou whaiaro me te clonogenicity o nga pūtau murine ES, engari ko te kore o SPRED2 ka whakaiti i te tipu me te whakanui ake i te apoptosis.I te wa o te rerekeetanga moata i roto i nga tinana embryoid, ka whakatairanga nga SPRED i te ahua pluripotent me te aukati i te rerekeetanga na reira ka roa te roa me te aukati i te wehenga mesodermal ki nga cardiomyocytes.Ko te LIF- me te tipu-whakaongaonga-whakaongaonga i whakaatu ko nga SPRED te aukati i te whakahohenga ERK / MAPK i roto i nga kamera ES murine.Heoi, karekau he paanga i kitea i runga i te whakahoahoatanga a LIF o te JAK / STAT3, PI3K / AKT ranei te huarahi tohu tohu e nga pūmua SPRED. E whakaatu ana matou ko nga SPRED e whakatairanga ana i te whakahou whaiaro me te aukati i te rereketanga mesodermal o murine ES pūtau ma te whakakore i te ERK / He ara tohu MAPK i roto i nga pūtau pluripotent.
