Hua

Ko te Linagliptin Intermediate F, e mohiotia ana ko te 3-aminopiperidine-1-carboxylic acid, he puhui matū nui i roto i te whakahiato o te linagliptin, he rongoa hei rongoa mo te mate huka momo 2.No roto a Linagliptin i te karaehe rongoa e kiia nei ko te aukati dipeptidyl peptidase-4 (DPP-4), e awhina ana ki te whakarite i nga taumata huka toto. He waahi nui a Linagliptin Intermediate F i nga waahanga whakamutunga o te whakahiatotanga o te linagliptin.Ka noho hei poraka hanga matua ki te hanga i te hanganga matū ahurei o te linagliptin ma te whai i nga raupapa tauhohenga.Ka whakamahia motuhake tenei takawaenga i roto i te whakahiatotanga o te mowhiti piperidine matua o te anga ngota o te linagliptin. Ka oti te whakahiato, ka mahi te linagliptin ma te aukati i te mahi enzymatic o DPP-4.Ka mahi nga aukati DPP-4 ma te aukati i te pakaru o nga homoni incretin, penei i te glucagon-like peptide-1 (GLP-1), he kawenga mo te whakaihiihi i te tuku insulin me te pehi i te hunanga o te glucagon.Ma te aukati i te DPP-4, ka whakaroahia e te linagliptin te mahi o enei homoni incretin, e arai ana ki te whakapai ake i te whakahaere o te huka toto i roto i nga tangata e mate ana i te mate huka momo 2. Ko te Linagliptin i te nuinga o te waa ka tohua hei taapiri mo te kai me te korikori tinana mo te whakahaere o te mate huka momo 2.E mohiotia ana mo te roa o te haurua o te ora, e taea ai te pai o te horopeta kotahi ia ra.Kua whakaatuhia te Linagliptin ki te whakaheke i nga taumata hemoglobin A1c, he tohu mo te wa roa o te whakahaere o te hukahuka, me te pai o te manawanui e nga turoro. ka kaha te pa ki te oranga o nga tangata whai mate huka momo 2.Ma te whai waahi ki te hanga i te hanganga matū ahurei o te linagliptin, ka taea e tenei takawaenga te hua whakamutunga ki te aukati i te DPP-4 me te whakapai ake i te mana glycemic. whakamahia mo te maimoatanga o te mate huka momo 2.Ko tana mahi ki te hanga i te hanganga ngota o te linagliptin e whakaatu ana i tona hiranga ki te hanga rongoa hei whakapai ake i te whakahaere huka toto me te whakapai ake i te whakahaeretanga o te mate huka.Ma te aukati i te DPP-4, ka awhina te linagliptin ki te whakahaere i nga taumata huka toto me te whai waahi ki te oranga katoa o te hunga whai mate huka momo 2.