Nicotinamide Riboside Cas: 1341-23-7
| Nama Putumōhio | XD91951 |
| Ingoa Hua | Nicotinamide Riboside |
| CAS | 1341-23-7 |
| Papanga Molecularla | C11H15N2O5+ |
| Taumaha rāpoi | 255.25 |
| Nga Taipitopito Rokiroki | Ambient |
| Waehere Rere Whakariterite | 2933199090 |
Whakatakotoranga Hua
| Te ahua | Te paura ma |
| Ahahay | 99% min |
Ka taea te whakamahi Nicotinamide Riboside i roto i te rangahau koiora o te ira circadian reprogramming transcriptome i roto i te ate kua tautuhia nga huarahi metabolic o te koroheketanga o te kiore.Ka piki ake ano te NAD + i roto i te roro roro me te whakaheke i te paheketanga o te hinengaro i roto i te tauira kiore transgenic o te mate a Alzheimer.
Ko te Nicotinamide adenine dinucleotide (NAD+) he coenzyme tino nui, ka whakahekehia ki te NADH, ka mahi hei kaihoko whakaheke hei koha irahiko mo te phosphorylation oxidative me te whakahiato ATP i roto i te mitochondria.Ko te NAD+ he mea nui mo nga whaakiki penei i te sirtuins, ADP-ribosyltransferases (ARTs), me te Poly [ADP-ribose] polymerases (PARPs) ka pau tonu e enei enzymes.Ko te tauwehenga NAD+/NADH he waahanga nui o te ahua redox o te pūtau.(Verdin 2015).I etahi kaute, ka uru te NAD, te NADP ranei e pa ana ki te hauwha o nga tauhohenga pūkoro katoa (Opitz Heiland 2015).He waahanga motuhake o NAD + i roto i te karihi, mitochondria, me te cytoplasm (Verdin 2015).
Ko te Nicotinamide riboside (NR) ka taea te huri ki te NAD + na roto i te takawaenga takawaenga ka huri hei nicotinamide mononucleotide (NMN) na NR kinase (Nrk) katahi ki NAD + na NMNATs.Ka kitea noa te NR i etahi kai engari he iti rawa te rahi (hei tauira, te iti o te awhe micromolar).I nga wa o mua, he uaua te whiwhi NR i roto i nga moni purea nui, engari na te ahunga whakamua i roto i nga tikanga whakahiato (Yang 2007), i te Pipiri 2013, ka hokona hei taapiri kai.
