Trimethoprim Cas: 738-70-5
| Nama Putumōhio | XD92385 |
| Ingoa Hua | Trimethoprim |
| CAS | 738-70-5 |
| Papanga Molecularla | C14H18N4O3 |
| Taumaha rāpoi | 290.32 |
| Nga Taipitopito Rokiroki | 2-8°C |
| Waehere Rere Whakariterite | 29335995 |
Whakatakotoranga Hua
| Te ahua | He paura ma, he kowhai-ma ranei |
| Ahahay | 99% min |
| Te Whakarewa | 199 - 203 Deg C |
| Nga konganuku taumaha | ≤20ppm |
| Ngaronga i te whakamaroke | ≤1.0% |
| Nga Taonga Paanga | ≤0.2% |
| Wairewa | He paku memeha i roto i te wai, he rire noa ki te waipiro, he kore e memeha ki te etera |
Ko te Trimethoprim he lipophilic me te ngoikore o te kawakore pyrimethamine class bacteriostatic agent.He paura tioata ma, tata ma ranei, he kakara, he kawa, he paku whakarewa ki roto i te chloroform, te waiwaro, me te acetone, engari karekau e rewa ki te wai me te tino memeha ki te wairewa waikawa acettic glacial.He tuāwhiorangi antibacterial e rite ana ki nga raau taero sulfa, engari he kaha te kaha antibacterial.He painga pai mo te rongoa Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Staphylococcus saprophyticus, me etahi atu momo huakita karamu pai me te kino.Engari kaore e whai hua ki te mate Pseudomonas aeruginosa.He iti ake i te 10 mg/L tana kukū aukati iti me te whakamahi anake he ngawari ki te whakapataritari i te huakita, na reira kaore i te whakamahia anake, me te nuinga o te waa ka honoa ki te rongoa sulfa hei hanga i te rongoa mo te rongoa haumanu o nga mate mimi, whekau. mate, mate manawa, koriri, enteritis, kirika taipoi, maningitis, otitis media, meningitis, sepsis me nga mate kiko ngohe.He painga ki te rongoa i te taipoi me te paratyphoid kaore i iti iho i te ampicillin;Ka taea hoki te whakakotahi ki nga raau taero sulfa roa mo te aukati me te maimoatanga o te mate pukupuku falciparum atete ki te tarukino.
Ko te kaupapa matua o te anti-huakita o te trimethoprim ko te whakararu i te paopaotanga folate i roto i nga huakita.Ko te mahi matua ko te aukati i te mahi o te reductase dihydrofolate i roto i nga huakita kia kore ai e taea te whakaheke te dihydrofolate ki te tetrahydrofolate.I te mea ko te whakahiato o te waikawa folic te waahanga nui o te koiora waikawa karihi, na reira ka aukati te hua i te waikawa nucleic huakita me te whakahiato pūmua.I tua atu, ko te hononga here o te trimethoprim (TMP) ki te huakita dihydrofolate reductase enzyme e rima nga wa te kaha ake i tera ki te mammalian dihydrofolate reductase.Ko te whakakotahitanga i waenga me nga raau taero sulfa ka taea te aukati i te rua ki te waikawa folic biosynthesis metabolism o te huakita kia puta ai he mahi synergistic e whakarei ake ai i te mahi antibacterial o nga raau taero sulfa, a ka taea te huri i te paanga antibacterial ki te huakita bactericidal e whakaiti ana i te tarukino-aukati. taumahatanga.I tua atu, ka taea hoki e te hua te whakarei ake i nga paanga antibacterial o etahi atu momo paturopi (penei i te tetracycline, gentamicin).
