I tukuna he kiore kotahi te horopeta o te tipu mai i te tipu phenolic antioxidant Quercetin (QC) i roto i te kore utu, liposome encapsulated me galactosylated liposome kapi 2 h i mua i te horopeta hepatotoxic o carbontetrachloride (CCl4, 40% v/v i roto i te hinu oriwa, 1 ml/kg b .wt).I roto i enei momo momo QC e toru i whakamatauria, ko te QC liposomal galactosylated anake i whai whakamarumaru nui ki te kino a CCl4 i te kino o te ate.I muri i te 24 haora o te werohanga (SC) ka kitea nga pūtau ate ate o te kiore ka pangia e te CCl4 te kino o te oxidative me te aro turukihia e te nui haere o te diene conjugated i roto i te membrane ate.Ko te pikinga-rua o te diene conjugated na te whakaurunga o CCl4 i heke ki runga ki te taumata noa e te galactosylated liposomal QC i mua i te maimoatanga.Ko te Carbontetrachloride te kino o te kirikiri i roto i nga pūtau ate, ka whakatauhia e te toto serum pathological me te kiko ate histopathological whakamātautau.Ko te kino o te membrane i te whakaurunga o CCl4 i arotakea ano e te heke o te taumata o te membrane plasma (PM) herea enzyme Na+/K+ ATPase mahi a ka piki ake na te maimoatanga o mua o te galactosylated liposomal QC.Ko te Carbontetrachloride te whakaheke nui i roto i nga taumata antioxidant endogenous enzymatic me te molecular endogenous i roto i nga pūtau ate. Ko te pouri i roto i te punaha antioxidant i roto i nga pūtau ate i tino aukatihia e te horopeta kotahi o te galactosylated lipsosomal QC i mua i te maimoatanga CCl4.Ko te tango a te ate o te QC i whakatauhia i muri i te 2 haora o te werohanga flavonoid (8.9 micromol/kg te taumaha tinana) (nga ahua kore utu, liposomal ranei) me te 85% o te QC i werohia i kitea i roto i te ate i roto i te take o te galactosylated liposomal QC.I te mea ko te 25% anake o te horopeta i werohia i kitea i roto i te ate i te wa i werohia te nui o te QC kore utu.Ko te Carbontetrachloride hoki i whakaawe i te whakarereketanga o te rere o te kiriuhi, ka arotakehia e te hekenga o te moroiti kiriuhi.Ko te maimoatanga o mua o te QC kore utu karekau he whakamarumaru ki te CCl4 na te pikinga o te kirikiri kiriuhi ate, engari ko te galactosylated liposomal QC he tino whakamarumaru ki te pikinga.Ko nga hua o tenei rangahau i kitea ko te QC i roto i te liposome galactosylated ka kaha te whakamarumaru ki te whara o te hepatocellular na te CCl4.
