Hua

Ko te kaupapa o tenei rangahau ko te whakataurite i te kaha o te valproate me te haloperidol ki te whakaheke i te taumata whakaohooho i roto i nga turoro e pa ana ki te tari ohorere.I tohua e matou 80 nga turoro e tino pukuriri ana ki te whiwhi i te konutai valproate (20 mg/kg) me te haloperidol intramuscular (5 mg/1 ml).I whangangahia te Agitation i te waahi tuatahi me te 30 min i muri i te werohanga tuatahi ma te whakamahi i te Agitation-Calmness Evaluation Scale (ACES), te Waahanga Pai me te Negative Syndrome Scale-Excited Component, me te Agitation Behavior Scale.Mo te 80 nga turoro i tukuna ki te konutai valproate, ko te toharite ± SD inenga ko 1541.5 ± 286 mg (awhe 940-2400).Ko te tikanga o nga tohu ACES i muri mai i te waahi mai i te raupapa ki te 30 min i muri i te werohanga tarukino ko 4.73 (SD = 1.93) mo te roopu valproate me te 5.45 (SD = 2.09) mo te roopu haloperidol (P = 0.028).Kaore he rereketanga nui i kitea i runga i nga huringa toharite 30 min i muri i te wawaotanga mo etahi atu unahi whakaohooho.Ko te waahanga nui ake o nga turoro i roto i te roopu haloperidol i kite i te whakahekenga kaha (36.2%, P <0.001) me nga tohu extrapyramidal (8.7%, P = 0.007) i whakaritea ki te roopu valproate (2.5% mo te whakahekenga kaha, kaore he manawanui mo nga tohu extrapyramidal).Ko nga kitenga e whakaatu ana i roto i te waahi mahi haumanu o te hinengaro ohorere, he rite te whai hua o te valproate intravenous rite haloperidol ki te whakaiti i te awangawanga, me te pai ake o te tohu haumaru.