DAPI (4,6-Diamidino-2-phenylindole dihydrochloride) CAS:28718-90-3 99% Kowhai paura
| Nama Putumōhio | XD90505 |
| Ingoa Hua | DAPI (4,6-Diamidino-2-phenylindole dihydrochloride) |
| CAS | 28718-90-3 |
| Tātai rāpoi | C16H15N5 · 2HCl |
| Taumaha rāpoi | 350.25 |
| Nga Taipitopito Rokiroki | Ambient |
| Waehere Rere Whakariterite | 2933998090 |
Whakatakotoranga Hua
| Te ahua | paura kōwhai |
| Te whakamatautau | 99% min |
| Mo te rangahau anake, kaua ma te tangata | Te whakamahi rangahau anake, kaua ma te tangata |
He maha nga mahi a te Melatonin i roto i nga mahi ahupūngao, a he rereke nga paanga ki te apoptosis i roto i nga pūtau noa me te mate pukupuku.Engari, kaore i te tino marama te tikanga o ana mahi antitumor.I roto i tenei rangahau, ka whakaatuhia e matou ko te melatonin te whakanui ake i te apoptosis-a-tunicamycin i roto i nga pūtau mate pukupuku MDA-MB-231.Ko te Melatonin te whakatika-whakahaere i te poroteina pro-apoptotic Bim kii i nga taumata whakawhiti i te aroaro o te tunicamycin.Ka whakakorehia e te Melatonin nga korero COX-2 i roto i te tunicamycin i roto i nga kamera MDA-MB-231.I tua atu, ko te aukati i te mahi COX-2 ma te whakamahi i te aukati COX-2, NS398, ka whakanui ake i te apoptosis-induced tunicamycin.He mea whakamiharo, kaore enei paanga i hono ki nga huarahi tohu tohu melatonin.Ko te toxin pertussis (he aukati pūmua Gi whānui) he luzindole ranei (he kaitukino kaikawe melatonin kore motuhake) kaore i huri i te paanga o te melatonin.I tua atu, ka aukatihia e te melatonin te mahi whakawhiti NF-κB i te tunicamycin, te whakawhitinga karihi p65, me te p38 MAPK mahi ivation.Ko te whakakorenga o te p38 MAPK i takawaenga-Melatonin i whai waahi ki te heke iho o te pumau COX-2 mRNA.Ka huihuia, ko o maatau hua e kii ana ko te melatonin te whakarei ake i te mahi antitumor na roto i te whakahaerenga ake o te whakaaturanga Bim me te whakahekenga o te whakaaturanga COX-2 i roto i nga pūtau MDA-MB-231 e tukinotia ana e tunicamycin.
