I te aroaro o te 2.8 mM D-glucose, beta-D-glucose pentaacetate (1. 7 mM) kua whakanuia te tukunga insulin mai i nga motu pancreatic kiore taratahi nui ake i te alpha-D-glucose pentaacetate.Waihoki, ko te pikinga ake o te whakaputanga o te insulin na te nateglinide (0.01 mM) he teitei ake i roto i nga moutere e mau ana ki te beta- kaua ki te alpha-D-glucose pentaacetate.He rereke, i te aroaro o te 2.8 mM D-glucose, alpha-L-glucose pentaacetate, engari ehara i te beta-L-glucose pentaacetate, ka tino whakanuia te whakaputanga insulin.Ko te kaha o te insulinotropic teitei ake o te beta-anomer o D-glucose pentaacetate i uru ki te meka i tino piki ake te tauwehenga takirua i waenga i te D-[U-14C] te hukahuka me te D-[5-3H] te whakamahi huka, engari ko te alpha-D. -Ko te pentaacetate huka i rahua.Ko enei kitenga ka whakamaoritia hei tautoko i te ariā ko te whakaihiihi o te tukunga o te insulin e enei esters te nuinga o te mea na to raatau taunekeneke tika ki tetahi kaikawe stereospecific, me te hiahia mo te whirihoranga o te C1 noa ki te beta-D-glucose pentaacetate me te alpha-L- te huka pentaacetate.
