Hua

He maha nga momo taapiri guanosine, ara ko te acyclovir (me tana valaciclovir prodrug-waha), penciclovir (i roto i tona ahua prodrug-waha, famciclovir) me te ganciclovir, e whakamahia nuitia ana mo te maimoatanga o te herpesvirus [ara te herpes simplex virus momo 1 (HSV-1), me te momo. 2 (HSV-2), te huaketo varicella-zoster (VZV) me/ranei nga mate cytomegalovirus tangata (HCMV)].I roto i nga tau tata nei, he maha nga momo taapiri guanosine hou kua whakawhanakehia, tae atu ki nga 3-membered cyclopropylmethyl and -methenyl derivatives (A-5021 me synguanol) me nga 6-membered D- me L-cyclohexenyl derivatives.Kua whakatauhia te mahi o te acyclic/carbocyclic guanosine analogues ki te whānuitanga o nga huaketo, tae atu ki te HSV-1, HSV-2, VZV, HCMV, me te momo herpesviruses tangata momo 6 (HHV-6), momo 7 (HHV- 7) me te momo 8 (HHV-8), me te huaketo hepatitis B (HBV).Ko nga taarua guanosine hou (arā, A-5021 me D- me L-cyclohexenyl G) i kitea he tino kaha ki te whakaeke i aua huaketo (HSV-1, HSV-2, VZV) e whakawaehere ana mo te kinase thymidine (TK) motuhake. ko ta raatau mahi patu huaketo (he waahanga iti rawa) ka whakawhirinaki ki te phosphorylation e te TK na te huaketo.I tohua ano te mahi antiviral ki te A-5021 ki te HHV-6 me te D- me te L-cyclohexenyl G ki te HCMV me te HBV.Ko te mahi pareiora o te acyclic/carbocyclic nucleoside analogues ka kaha te kaha o te waikawa mycophenolic, he aukati kaha o te inosine 5'-monophosphate (IMP) dehydrogenase.Ko nga taapiri hou o te guanosine carbocyclic (arā, A-5021 me D- me L-cyclohexenyl G) e mau ana te oati nui, ehara i te mea he rongoa pareketo anake mo te maimoatanga o nga mate herpesvirus, engari ano hoki he kaihoko antitumor mo te whakakotahitanga o te rongoa ira / chemotherapy o te mate pukupuku, engari ko (he wahanga o) nga pūtau puku kua tukuna e te ira TK viral (HSV-1, VZV) TK.