Hua

Ko te whakarereketanga o te triglyceride (TG) pākia i roto i nga pūtau uaua ngohe ngohe (SMC) tera pea ka hono ki etahi tohu tohu, ahakoa kaore ano kia whakamaramatia.Ko te Adipose triglyceride lipase (ATGL) he mahi nui TG catalytic i roto i nga pūtau adipotic me te kore-adipotic.I roto i te rangahau o tenei wa, i wehea e matou te SMC mai i nga kiore ngoikore o ATGL (ATGL (-/-) mSMC).Ko te ATGL (-/-) mSMC i whakaatu i te whakaemi TG mahorahora me te whakautu mitogenic iti me te whakakitenga o te actin muscle (SMA) maeneene ki te ATGL (+/+) mSMC.Ko te ōrau o ngā pūtau pai _-galactosidase e pa ana ki te pakeketanga i piki ake i roto i te ATGL(-/-)mSMC.Ko te PCR-wa-tuuturu ka whai i te tirotiro me te aro turuki i te raupapa DNA kua kitea te whakaaturanga o te glucokinase (1.7-fold), lipoprotein lipase (3.8-fold) me te interleukin-6 (3.7-fold) me te whakaaturanga whakaheke-whakarite o te tipu endothelial vascular tauwehe-A (0.2-fold), momo I collagen (0.5-fold), me te huri tauwehe tupu-_ (0.4-fold) i roto i te ATGL(-/-)mSMC whakaritea ki ATGL(+/+)mSMC.I muri mai, i whakamatauhia te whakawhiti ira ectopic o te ATGL tangata ma te whakamahi i te doxycycline (Dox)-regulatable myc-DDK-tagged adenovirus vector (AdvATGL).Ko te mate o AdvATGL i hua mai i te whakahekenga o te whakaemi TG me te whakautu mitogenic teitei me te whakaaturanga SMA, me te heke i roto i nga tau pūtau tawhito i roto i te ATGL (-/-) mSMC.I tua atu, ko te tauira whakaputa ira ira i roto i te ATGL (-/-) mSMC ka taea te whakatika.Ko o maatau korero e kii ana ko te ATGL (-/-) mSMC he tohu tohu motuhake e pa ana ki te pathogenesis vascular.Ko te whakakikorua o nga tohu tohu SMC e hono ana ki te paopaotanga lipid ka waiho hei kaupapa rongoa.