Hua

Ko Rosuvastatin Intermediates ZD9, e mohiotia ana ko Z-4-(4-Fluorophenyl)-6-Isopropyl-2-[(N-Methyl-N-Methylsulfonyl)Amino]Pyrimidin-5-Yl, he pūhui matū e mahi nui ana. takawaenga ki te whakahiato o te rongoa whakaheke cholesterol Rosuvastatin.Ka whai waahi nui tenei takawaenga ki te hanga o Rosuvastatin, no te karaehe o nga raau taero e kiia nei he statins. Ko te ZD9 te mahi hei puhui o mua i roto i te whakahiatotanga maha o Rosuvastatin.I te wa o te mahi whakangao, he maha nga huringa matū a ZD9 kia puta ai te hua whakamutunga, Rosuvastatin.Ko tenei whakahiato ka uru ki te taapiri i etahi atu roopu mahi ki runga i te ngota ZD9, ka puta te hanga o te whakauru rongoa kaha, Rosuvastatin. Kei te whakamahia nui a Rosuvastatin mo te maimoatanga o te hypercholesterolemia, he ahuatanga e tohuhia ana e te nui o te cholesterol i roto i te toto.Ka mahi ma te aukati i te enzyme HMG-CoA reductase, e whai waahi nui ana ki te whakahiato cholesterol i roto i te tinana.Ma te whakaiti i te hanga o te cholesterol, ka awhina a Rosuvastatin ki te whakaheke i nga taumata cholesterol katoa, tae atu ki te cholesterol iti-density lipoprotein (LDL), e kiia ana he cholesterol "kino". me te tikanga whai hua.Ko te mahi hei poraka hangahanga e mau ana i nga tauhohenga matū, e arahi ana ki te hanga i nga here motuhake me nga roopu mahi e tika ana mo te mahi rongoa a Rosuvastatin. te hanganga tika o te hua whakamutunga.Ki te kore te ZD9, ka kore e taea te whakahiato o Rosuvastatin, ka aukati i te hanga o tenei rongoa whakaheke cholesterol nui. Hei whakarāpopototanga, ko Rosuvastatin Intermediates ZD9 te mahi hei takawaenga nui mo te whakahiatotanga o te rongoa whakaheke cholesterol, Rosuvastatin.Ka noho hei paraka hangahanga ka huri i nga huringa matū kia puta ai te whakauru rongoa kaha.Ma te whai waahi nui ki te mahi whakaputa, ka whai waahi a ZD9 ki te waatea o tetahi rongoa nui mo te maimoatanga o nga taumata cholesterol teitei i roto i nga turoro.