Hua

Tert-butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino) Ko te pyridin-3-yl) piperazine-1-carboxylate he pūhui me te kaha nui ki te matū rongoa me te whanaketanga tarukino.Ko tana hanganga rapoi matatini e whakaatu ana i nga momo tono ka taea. Kei roto i tenei puhui he piperazine-1-carboxylate matua, he scaffold e whakamahia nuitia ana i roto i te matū rongoa na tona ahuatanga maha me te whānuitanga o nga momo whaainga tarukino.Ko te waahi o te piperazine moiety ka taea te taunekeneke ki nga momo kaiwhakawhiwhi me nga enzymes, ka waiho hei kaitono pai mo te whakawhanaketanga o nga kaihoko rongoa.Ko te 6-(1-butoxyvinyl) -8-cyclopentyl-5-methyl-7-oxo-7, Ko te roopu 8-dihydropyrido [2,3-d] pyrimidin-2-yl i roto i te hanganga e whakarato ana i nga mahi rongoa.Ko enei pyrido [2,3-d] pyrimidine derivatives kua tino rangahauhia mo o raatau taonga anti-inflammatory, antiviral, me te mate pukupuku.Ko nga roopu cyclopentyl me te methyl ka whai waahi ki te lipophilicity o te puhui, ka taea te whakarei ake i te kaha o te pūtau me te bioavailability.Ko te roopu tert-butyl ester e whakarato ana i te pumau ki te puhui me te ngawari ki te huri ki etahi atu roopu mahi, ka taea te whakarereke atu, te whakaheke ranei.He mea nui tenei ngawari i roto i te matū rongoa, na te mea ka taea e ia te whakawhanaketanga o nga puhui kaha ake me te whiriwhiri.E tohu ana tenei ka pa pea te puhui ki nga huarahi tohu tohu intracellular a ka taea te tirotirohia mo tona kaha ki te whakarereke, ki te kaitukino ranei o nga kaiwhakawhiwhi motuhake e uru ana ki nga ahuatanga mate. Ko te hanganga whanui o tert-butyl 4-(6-(6- (1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate tona kaha ki te whakawhanaketanga o nga rongoa hou.Ka whai waahi ki te tirotiro i te aukati i te whanariki, te herenga kaiwhiu, me te whakarereketanga o nga momo tikanga koiora. Ma te tirotiro me te arotautanga, ka noho pea tenei puhui hei puhui arahi mo te whanaketanga o nga raau taero e aro ana ki te mate pukupuku, te mumura, me era atu mate.Ko ona ahuatanga hanganga ahurei me nga mahi koiora pea ka waiho hei puhui whakamere mo etahi atu rangahau me te whanaketanga i roto i te mara matū rongoa. Hei mutunga, tert-butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl- Ko te 5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate e mau ana te kupu whakaari hei puhui maha mo te whanaketanga tarukino.Ko tana hanganga matatini me nga mahi rongoa ka taea e ia hei kaitono whakahirahira mo te tirotiro ano hei kaihoko rongoa mo nga momo mate me nga ahuatanga.