Uridine,2′-deoxy-5-ethynyl- Cas:61135-33-9
| Nama Putumōhio | XD90589 |
| Ingoa Hua | Uridine,2'-deoxy-5-ethynyl- |
| CAS | 61135-33-9 |
| Tātai rāpoi | C11H12N2O5 |
| Taumaha rāpoi | 252.23 |
| Nga Taipitopito Rokiroki | -20°C |
| Waehere Rere Whakariterite | 29349990 |
Whakatakotoranga Hua
| Te ahua | Ma ki te Karaka ki te Kakariki paura ki te karaihe |
| Te whakamatautau | ≥99% |
I whakahaerehia tenei rangahau ki te tirotiro i te kaha o te tipu o nga peptides soy huawhenua ki runga i nga pūtau kakau pakeke (ASCs) i te kore o te serum me o raatau tikanga mahi.Ko te tipu o nga pūtau mesenchymal mesenchymal (ADSCs) i ahu mai i te kiko o te tangata me te taura toto-take mesenchymal stem cell (CB-MSCs) i tukinotia ki nga peptides soy i kitea he tino piki ake i runga i te 3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide me te Click-iT 5-ethynyl-2'-deoxyuridine rere cytometry assay.I tua atu, ko nga peptides soy i arahina ki te phosphorylation o te p44 / 42 MAPK (ERK), te whainga mammalian o te rapamycin (mTOR), te p70 S6 kinase, te S6 ribosomal protein (S6RP) me te eukaryotic initiation factor 4E (eIF4E) i roto i nga ADSCs.I tua atu, ko te tātaritanga ine o nga cytokines i whakaatu ko te whakaputanga o te huringa tipu-beta1 (TGF-β1), vascular endothelial growth factor me te interleukin-6 i tino piki ake hei whakautu ki te maimoatanga me nga peptides soy i roto i nga ADSC me CB-MSCs.Waihoki, ko te phosphorylation peptide-induced soy o te ara ERK / mTOR / S6RP / eIF4E i aukatihia hei whakautu ki te maimoatanga o mua me te PD98059, he aukati ERK motuhake.I tua atu, ko te whakakore i te TGF-β1 na roto i te PD98059 pretreatment me te heke o te heke o te pikinga ADSC i whakaatu ko te TGF-β1 te whakatairanga i te phosphorylation o te mTOR / S6RP / eIF4E.Huihuihia, ko nga hua o tenei rangahau e tohu ana ko te hanga TGF-β1 e whakawhirinaki ana ki te ERK he mahi nui ki te whakatipu peptide soy-induced o ADSCs i raro i nga tikanga kore-serum. Copyright © 2012 Elsevier Inc. Katoa te mana.
