Hua

Ko te fibrosis pulmonary idiopathic e kiia ana he whara te pukahukahu na nga momo hāora tauhohe (ROS), ka whai muri mai ko te fibrosis kino.He nui te mahi a te tauwehe tipu hurihuri (TGF)-β1 i roto i te tau myofibroblast ki tenei fibrosis kino.I kitea e matou ko te mepenzolate bromide (mepenzolate), kua whakamahia hei rongoa ki te rongoa i nga mate o te kopu, he taonga whakaheke ROS.I roto i te rangahau o naianei, i tirotirohia e matou te paanga o te mepenzolate ki runga i te bleomycin-induced pulmonary fibrosis me te korenga o te huhu i roto i nga kiore.I aromatawaihia te kaha o te fibrosis pulmonary e te arotake histopathologic me te whakatau i nga taumata hydroxyproline.I aromatawaihia te mahi a te pukahukahu me te mahi manawa [kaha kaha (FVC)] ma te whakamahi i te hikoi rorohiko.I arotakea ano te mahi o te manawa ma te aro turuki i te haunga o te hau (SpO2).Ko te whakahaere intratracheal o te mepenzolate i mua i te maimoatanga bleomycin i whakaitihia te whānuitanga o te fibrosis pulmonary me nga huringa i roto i nga miihini pūkahukahu me te arahi ki te whakaora nui o te FVC me te SpO2 i whakaritea ki te mana whakahaere.I tua atu, ko te mepenzolate he hua rongoa ahakoa i tukuna i muri i te whakawhanaketanga o te fibrosis.Ko te whakahaeretanga o te mepenzolate i aukati hoki i te mate o te bleomycin-induced pulmonary cell me nga urupare mumura me te piki haere o te nama myofibroblast.I whakahekehia ano e te Mepenzolate te mahi NADPH oxidase me te taumata TGF-β1 kaha, te whakanui ake ranei i te mahi glutathione S-transferase (GST) i te aroaro o te maimoatanga bleomycin.Ko enei hua e whakaatu ana ko te whakahaere intratracheal o te mepenzolate i whakaiti i te bleomycin-induced pulmonary fibrosis me te mate o te huhu i roto i nga kiore.Ko enei paanga ka pa mai pea na te awe o tenei tarukino ki runga i nga mahi NADPH oxidase me TGF-β1 me tona awe whakaihiihi i te GST.