E rua nga momo riterite heptane [4.1.0] heptane o te glycosidase inhibitor galacto-validamine, (1R*,2S,3S,4S,5S,6S*)-5-amino-1-(hydroxymethyl)bicyclo[4.1.0]heptane -2,3,4-triol, kua whakahiatohia i roto i nga hikoinga 13 mai i te 2,3,4,6-tetra-O-benzyl-D-galactose.Ko nga mahi aukati o nga amine herea e rua, me o raatau acetamides e rite ana, i inehia ki te arumoni alpha-galactosidase enzyme mai i te pini kawhe me te E. coli.Ko te ngohe o te whanau glycosyl hydrolase GH27 enzyme (bean kawhe) i whakataetaehia e te 1R,6S-amine (7), he hononga honohono i tohuhia e te uara K (i) o 0.541 microM.Ko te GH36 E. coli alpha-galactosidase i whakaatu i te tino ngoikore o te hononga honohono me te 1R,6S-amine (IC(50)= 80 microM).Ko te diastereomeric 1S,6R-amine (9) i herea ngoikore ki nga galactosidases e rua, (pi kawhe, IC(50)= 286 microM) me (E. coli, IC(50)= 2.46 mM).
